Antimicrobial resistance poses a global health crisis wherein common and treatable infections have been becoming life-threatening. As bacterial resistance has emerged either through mutations in the genome or the acceptance of genes conferring resistance by horizontal gene transfer (HGT) against clinically relevant antibiotics, and multi-drug resistance strains have become widespread both in hospitals and the community, in all WHO regions, the development of new drugs has become of critical importance. However, the development of new antibiotics has become scientifically more complex, more expensive, and more time-consuming. The costs to develop a new drug is at least $1 billion and no new class has been found since 1987. Historical data show that, generally, only 1 out of 5 drugs that reach the initial phase of testing in humans will receive approval from the Food and Drug Administration.

One way to reposition drugs is to use them in combination with antibiotic resistance breaker. However, the mechanism by which antibiotic resistance breaker re-sensitize bacteria to antibiotic is not yet fully understood. So, my research interests focus on screening and understanding of the mechanism of action of potential antibiotic resistance breakers which can be used as a tool for breaking antibiotic resistance.

• Payasi A, Sanwal GG. Ripening of climacteric fruits and their control. J. Food Biochem.,  2010; 35:679-710.
• Payasi A, Mishra NN, Chaves ALS, Singh R. Biochemistry of fruit softening: An overview. Physiol. Mol. Biol. Plants., 2009;15:103-113.
• Payasi A, Sanwal R, Sanwal GG. Microbial pectate lyases: characterization and enzymological properties. World J. Microbiol. Biotechnol., 2009;25: 1-14.
• Mishra NN, Prasad T, Sharma N, Payasi A, Singh R, Prasad R, Gupta DK. (2007). Pathogenicity and drug resistance in C. albicans and yeast species. Acta Microbiol. Immunol.  Hung. 2007;54:201-235.
• Payasi A, Sanwal GG. Biochemistry of fruit ripening. Indian J. Agri. cult. Biochem., 2005;   18:51-60.

• 2008-2009 Post-doctoral fellow, Department of Genomics, University of   Federal, Pelotas, Brazil
• 2000-2006 Doctor of Philosophy (PhD) in Biochemistry,University of Lucknow, Lucknow,India
• 1998-2000 Master of Science (M.Sc.) in Biochemistry), APS University, Rewa, MP, India
• 1996-1998 Bachelor of Science (B.Sc.) APS University, Rewa, MP, India

• Payasi A, Kumar S, Chaudhary S, Aggarwal A. 2025. Influence of Extracellular Zinc on Metallo-Β-Lactamase Activity And Carbapenem Susceptibility. Infection BSAC Winter Conference. 27-28 October, 2025, Birmingham, UK.
• Vishwakarma KK, Payasi A, Chaudhary S, Aggarwal A. 2025. VRP-034 Attenuates Polymyxin B Nephrotoxicity Despite Higher Dosing: a Comprehensive Preclinical Evaluation. Infection BSAC Winter Conference. 27-28 October, 2025, Birmingham, UK.
• Chaudhary, S., Payasi, A., Kumar, S., and Yadav, M., Ahluwalia, M. 2024. EA095. Comparative in Vitro Efficacy Study of VRP-034 and Polymyxin B in Genetically Characterized Pathogens From Clinical Settings in India. ASM-ESCMID.
• Payasi A, Kumar S, Yadav M. In Vitro Efficacy Study of VRP-034 in Genetically Characterised Gram Negative Pathogens Responsible for Human Infections presented at the 33rd ECCMID 2023,which took placeon line 15-18 April, 2023.
• Payasi A, Kumar S, Chaudhary S, Aggarwal A. In Vitro Activity of VRP-034 Against Metallo-Beta-Lactamases Producing Gram-Negative Pathogens Responsible for Human Infections presented at the 32nd ECCMID 2022,which took place on line 23-26 April, 2022.
• Payasi A, Chaudhary S, Chaudhary M, Sharma A, Aggarwal A. In vitro Cytotoxicity Assessment of a Novel Formulation of Polymyxin B (VRP-034). presented at the 31st ECCMID 2021,which took place on line 9-12 July, 2021.
• Chaudhary S, Roy D, Sachdeva A, Payasi A, Aggarwal A. Caco-2 permeability assessment and in vivo pharmacokinetics of VRT001-C (oral ceftriaxone). presented at the 30th ECCMID 2020,which took place on line 9-12 July, 2021.
• Payasi A, Ganguly K, Roy D, Sachdeva A, Chaudhary M, Chaudhary S, Aggarwal A. Poster number L0029 entitled “Pharmacodynamic Assessment of VRT001-C (Oral Ceftriaxone) vs. Intravenous Ceftriaxone Against Escherichia coli in the Neutropenic Murine Thigh Infection Model” presented at the 29th ECCMID 2019,which took place in Amsterdam, Netherlands, 13 – 16 April 2019.
• Mandale P, Mir MA, Chaudhary S, Chaudhary M, Sood R, Patil NS, Narang S, Payasi A, Shameem M, et al. Poster number 1974 entitled “Ceftriaxone-Sulbactam-EDTA vs. Meropenem in PLEA (a Phase 3, Randomized, Double-blind Trial): Outcomes by Baseline MIC in Adults with Complicated Urinary Tract Infections or Acute Pyelonephritis” presented at IDWeeK-2018, October 3-7, 2018 at the Moscone Convention Center, in San Francisco, CA.
• Girotra R, Payasi A, Chaudhary M, Patil NS, Mir MA, Chaudhary S, Mandale P, et al. Poster number 1373 entitled “Activity of Ceftriaxone-Sulbactam-EDTA Against Multi-Drug Resistant A. baumannii, P. aeruginosa and Enterobacteriaceae Isolates (WHO Critical Priority Pathogens) Collected from Various Hospitals in India” presented at IDWeeK-2018, October 3-7, 2018 at the Moscone Convention Center, in San Francisco, CA.
• Mir MA,  Chaudhary S,  Chaudhary M, Payasi A, Patil NS, Mandale P, Girotra R, Fatima N, et al. Poster number 1948 entitled “Ceftriaxone-Sulbactam-EDTA vs. Meropenem: Analysis of failed patients with assessment of MIC increases and changes in genotypic profile in PLEA (a Phase 3, Randomized, Double-blind Clinical Trial in Adults with Complicated Urinary Tract Infections or Acute Pyelonephritis)” presented at IDWeeK-2018, October 3-7, 2018 at the Moscone Convention Center, in San Francisco, CA.
• Chaudhary M, Payasi A, Patil S. Poster number 192 entitled “Antimicrobial Resistance in India - Genotypic Characterization and Exploring the Role of EDTA as an Antibiotic Resistance Breaker” presented at ASM/ESCMID conference on drug development to meet the challenges of antimicrobial resistance September 6-8, 2017  in Boston, MA.
• Awarded gold medal for poster presentation in a International conference “Molecular Pharmacology, Drug discovery and Nanopharmaceuticals” held in Chitkara College of Pharmacy, Chitkara University, Rajpura, Distt Patiala, Punjab. from March 27-28, 2015.
• Payasi A, Gupta A, Chaudhary M. Awarded silver medal for poster presentation in a International conference “Manthan” held in Venus medicine Research Centre, Baddi from January 14-16, 2010.
• Payasi A (2007). Attended a workshop on immobilized Enzyme Technology and Biosensor  organized by Department of Biotechnology, New Delhi, at Rohtak, Haryana, from Aug. 24 to Sep. 2.
• Payasi A, Misra PC, G. G. Sanwal (2005). Mg2+ requirement pectate lyase  from banana fruits. Presented the poster in the 74th annual meeting of biochemical society Lucknow chapter, on Nov,7-10  at Central Drug Research Institute Lucknow.
• Payasi A, Misra PC, G. G. Sanwal (2003). Effect of phytohormones on  Pectate lyase activity. Presented the poster in the national conference on “Soil biodiversity and applied biology of plant” on Nov, 8-10 at Lucknow University, Lucknow India.
• Participated in 89^th session of Indian Science Congress-2002 from January 3-7, 2002 at University of Lucknow, Lucknow in the section of Biochemistry, Biophysics and molecular Biology.